Endocrine Abstracts

Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcaemia and elevated or inappropriately normal levels of parathyroid hormone (PTH), which is excessively secreted from one or more parathyroid glands. Classical disease is nowadays only seldom seen due to widespread biochemical screening. Most patients are asymptomatic and have more subtle, but clinically important skeletal and renal involvement. A normocalcaemic variant of the di...

A 49-year-old previously healthy man suddenly felt severe and constant bilateral lumbar pain. Clinical examination was otherwise normal. Abdominal CT scan showed subacute hematomas in both adrenal glands (sized 10 cm right and 8 cm left). Basic laboratory tests were completely normal. Hormonal testing excluded pheochromocytoma and other hormonally active adrenal tumors. Adrenal insufficiency was confirmed by short Synacthen test and substitution therapy with hydrocortisone was...

A 49-year-old previously healthy man suddenly felt severe and constant bilateral lumbar pain. Clinical examination was otherwise normal. Abdominal CT scan showed subacute hematomas in both adrenal glands (sized 10 cm right and 8 cm left). Basic laboratory tests were completely normal. Hormonal testing excluded pheochromocytoma and other hormonally active adrenal tumors. Adrenal insufficiency was confirmed by short Synacthen test and substitution therapy with hydrocortisone was...

Objective: Limited data suggest that the rebound increase in bone resorption and rapid bone mineral density (BMD) decline following sudden interruption of denosumab therapy can be avoided in patients previously treated with bisphosphonates. We aimed to compare BMD changes in osteoporotic patients after denosumab discontinuation regarding their previous bisphosphonate (BP) therapy.Material and methods: There were 14 women (age 69 years, BMI 23.1 kg/m...

The ideal antiresorptive agent to preserve or further increase bone mineral density (BMD) following teriparatide treatment is not known. We aimed to compare BMD changes after one year of therapy with denosumab or bisphosphonates in osteoporotic patients who had completed treatment with teriparatide. We retrospectively analyzed 140 women (age 74 years, 26 years from menopause, BMI 27 kg/m2 on average) with severe postmenopausal osteoporosis who had been treated betwe...

Serum urate level has recently been associated with increased bone mineral density (BMD). Teriparatide, an osteoanabolic medication for osteoporosis, is associated with increased incidence of hyperuricemia. Hence, we hypothesized that changes in serum urate are associated with changes in BMD and procollagen type 1 N-terminal propeptide (P1NP) during treatment with teriparatide.We collected data from 151 women (mean age 72 years, mean BMI 26.6 kg/m2<...

Introduction: Primary aldosteronism (PA) is an important cause of secondary hypertension, associated with increased cardiovascular morbidity and mortality rate compared to patients with essential hypertension.Case report: We report the case of a 59-year-old Caucasian male with a medical history of dilatative cardiomiopathy, paroxysmal atrial fibrillation and bifascicular block who was admitted to the E.R. with shortness of breath, headache, palpitations,...

Introduction: Results of the first European real-world evidence from retrospective cohort of ACRONIS study previously confirmed the efficacy and tolerability of LA-PAS in heavily pre-treated, uncontrolled acromegaly patients. Here, we report results of the second interim analysis reflecting the prospective cohort.Methods: Patients who were treated with LA-PAS for ≥6 months were included in this analysis. The primary objective was to document treatm...